Tuesday, January 16, 2024
Pre-meeting workshop: Bacterial Genomics
8:30-9:00 Strain-level Characterization of Metagenomic Sequencing Data
Todd Treangen, Rice University
9:00-9:10 Interactive demo
9:10-9:50 Advance Topics Lecture & Hands-on Training
9:50-10:00 Q&A
10:00-10:30 Networking
10:30-11:15 Methods for Pathogen Epidemiology Using Whole Genome Sequencing
Jennifer Spinler, Baylor College of Medicine
11:15-11:45 Interactive Demo
11:45-12:00 Q&A
Day 1 – Wednesday, January 17, 2024
Mechanisms of Resistance and Drug Discovery
7:00-8:30 Registration
7:30-8:30 Career Mentoring ID Fellows-Event Hall
Adarsh Bhimraj, MD, Houston Methodist Hospital
Pablo Okhuysen, MD, MD Anderson Cancer Center
8:30-8:35 Welcome
Natasha Kirienko, PhD
Rice University, Houston, TX
Cesar A. Arias, MD, PhD
Houston Methodist Research Institute and Weill Cornell Medical College, Houston, TX
Suzanne Tomlinson, PhD, MBA
Gulf Coast Consortia
Session 1
Conveners: Natasha Kirienko, PhD, Rice University, Houston, TX
Taryn Eubank, PharmD, University of Houston, Houston, TX
8:35-8:55 Antibiotic Resistance and Clostridioides difficile: A Driving Force for Treatment Failures and Considerations for New Drug Development
Chetna Dureja, PhD
Texas A&M, Houston, TX
8:55-9:15 Emergence of Clonal Dominance in Clinical Isolates of Multidrug-Resistant P. aeruginosa
Natasha Kirienko, PhD
Rice University, Houston, TX
9:15-9:35 Cell Membrane Remodeling in Gram-Negative Bacteria
Stephen Trent, PhD
University of Georgia, Athens, GA
9:35-10:05 Vendor Show and Networking-Prefunction and Event Hall
Session 2 T32 Trainee Symposium: Texas Medical Center Training Program on Antimicrobial Resistance (TP-AMR), Emory Training Program on Antimicrobial Resistance, University of Pittsburgh Training Program on Antimicrobial Resistance
Conveners: William Shropshire, PhD, MD Anderson Cancer Center, Houston, TX
Martina Golden, BA, BS, Emory University, Atlanta, GA
10:05-10:20 Impact of Antibiotic Treatment on Lactobacillus Population Dynamics and Intestinal Immune Homeostasis
Dormarie Rivera-Rodriguez, BS
Emory University, Atlanta, GA
10:20-10:35 Non-Antibiotic Based Therapeutics to Combat Multi Antibiotic Resistant Bacteria
Paul Kilgore, PhD
University of Texas Medical Branch, Galveston, TX
10:35-10:50 Functional Genomics of Difficult-to-Treat Enterococcal Isolates and Their Viral Adversaries
Madison E. Stellfox, MD, PhD
University of Pittsburgh
10:50-11:05 Fusobacterium nucleatum Enoyl-ACP Reductase II (FabK): A Narrow-Spectrum Drug Target
Jacob Rutherford, BS
Texas A&M Health Science Center, Houston, TX
11:05-11:35 Keynote Lecture
Probiotics for Staphylococcus aureus: A Translational Approach
Michael Otto, PhD
NIH, Bethesda, MA
11:35-1:45 Lunch/Rapid Fire/Poster Session-Event Hall
11:35-12:15 Lunch
12:15-12:45 Rapid Fire
LiaR-Dependent Gene Expression Contributes to Antimicrobial Responses in Group A Streptococcus
Luis Alberto Vega, PhD, University of Texas Health Science Center at Houston, Poster 6
Alternating Magnetic Fields Enhance the Effect of Antibiotics on Metal-Associated Biofilms
Miranda Hairgrove, University of Texas Southwestern Medical Center, Poster 2
Mutations in LiaF of Enterococcus faecalis Associated with Daptomycin Resistance (DAP-R) Differentially Affect Interaction Dynamics with the Histidine Kinase LiaS in Lipid Nanodiscs
Kara Hood, PhD, Houston Methodist Research Institute, Poster 3
Determining the Molecular Mechanism of Antibiotic Resistance by BpeEF-OprC Pump in Burkholderia thailandensis
Mithila Farjana, BSc, University of Oklahoma, Poster 1
Investigating the Potential of Bacteriophage to Limit Uropathogenic E. coli Colonization
Bishnu Joshi, MSTAH, PhD, Baylor College of Medicine, Poster 4
12:45-1:45 Poster Session, Poster #s 1-28 (please note poster 5 will present on day 2)
Session 3
Conveners: Tim Palzkill, PhD, Baylor College of Medicine, Houston, TX
Cecilia Tran, PharmD, Houston Methodist Research Institute, Houston, TX
1:45-2:05 Penicillin Resistance in Group A streptococci
Randy Olsen, MD, PhD
Houston Methodist and Weill Cornell Medical College, Houston, TX
2:05-2:25 Novel Therapeutics Against Fungal Infections
Minh-Hong Nguyen, MD
University of Pittsburgh, Pittsburgh, PA
2:25-2:45 Antibiotic Resistance in Neisseria Gonorrhoeae
Yonatan Grad, MD, PhD
Harvard School of Public Health, Boston, MA
2:45-3:15 Networking Break
Session 4 NIH Antimicrobial Resistance Leadership Group (ARLG)
Early-stage investigators
Conveners: Anthony Harris, MD, University of Maryland
Vance Fowler, MD, Duke University
3:15-3:30 Strain Temporal Engraftment and Persistence after Fecal Microbiota Transplantation
Ahmed Babiker, MSc, MBBS
Emory University School of Medicine
3:30-3:45 Discovering Disparities in Clinical Characteristics and Outcomes Among Patients Treated in US Hospitals for Carbapenem-resistant Enterobacterales (Bloodstream) Infections
Felicia Ruffin, PhD
Duke University
3:45-4:00 Emerging S. aureus Antimicrobial Resistance and Current Prescribing Practices for Patients Presenting to US Emergency Departments with a Purulent Skin and Soft Tissue Infection
Jesus Torres, MD, MPH
University of California, Los Angeles, David Geffen School of Medicine
4:00-4:15 Understanding the Molecular Epidemiology of Non-CTX-M ESBL-producing Enterobacterales in the MidAtlantic United States
Dariusz Hareza, MD
Johns Hopkins University School of Medicine
Session 5 Selected Abstracts
Convener: Sam Shelburne, MD, PhD, MD Anderson Cancer Center, Houston, TX
Kara Hood, PhD, Houston Methodist Research Institute, Houston, TX
4:15-4:30 Evaluation of De Novo Fatty Acid Biosynthesis as a Narrow-Spectrum Approach for Clostridioides difficile Infection
Chetna Dureja, PhD
Texas A&M University Institute of BioSciences and Technology
4:30-4:45 Cefepime Heteroresistance is Prevalent Among Clinical Pseudomonas Aeruginosa Bloodstream Isolates and is Associated with Emergence of Resistance in Patients with Hematologic Malignancies
Stephanie Egge, MD
Oregon Health & Science University
4:45-5:00 Rates of Resistance and Heteroresistance to Newer ß-lactam/ß-lactamase Inhibitors for Carbapenem-Resistant Enterobacterales
Christina Lin, MD, PhD
Emory School of Medicine
5:00-6:00 Reception-Prefunction
Day 2 – Thursday, January 18, 2024
Translational and Clinical Aspects of Antibiotic Resistance
7:00-8:30 Registration
7:30-8:30 Career Mentoring: Research Pathways for International Graduates-Event Hall
Jose Serpa, MD, PhD, Baylor College of Medicine
Anna Konovalova, PhD, University of Texas Health Science Center at Houston
Session 6
Conveners: Tor Savidge, PhD, Baylor College of Medicine, Houston, TX
8:30-8:55 Intrinsic Antibiotic Resistance in Pseudomonas aeruginosa
Barbara Kazmierczak, PhD
Yale University, New Haven, CT
8:55-9:20 Mucus-Degrading Microbiome and Graft-Versus-Host Disease
Robert Jenq, MD
MD Anderson Cancer Center, Houston, TX
9:20-9:45 Novel Dug Combinations to Address Antimicrobial Resistance
Warren Rose, PharmD, MPH
University of Wisconsin, Madison, WS
9:45-10:15 Vendor Show and Networking-Prefunction and Event Hall
Session 7 T32 Trainee Symposium: Texas Medical Center Training Program on Antimicrobial Resistance (TP-AMR), Emory Training Program on Antimicrobial Resistance, University of Pittsburgh Training Program on Antimicrobial Resistance
Conveners: Paul Kilgore, PhD, University of Texas Medical Brach, Galveston, TX
Madison E. Stellfox, MD, PhD, University of Pittsburgh, Pittsburgh, PA
10:15-10:30 Investigating the Role of Metabolism for Antibiotic Combination Therapies in Pseudomonas Aeruginosa
Martina Golden, BA, BS
Emory University, Atlanta GA
10:30-10:45 Basis of Commensal Bacillota Resistance to a Novel PolC-type DNA Polymerase III Inhibitor, Ibezapolstat, and the “Narrower” Spectrum of Activity Towards Clostridioides difficile
Jacob McPherson, PharmD
University of Houston, Houston, TX
10:45-11:00 Differences in Virulence Between the Two Clades of Multidrug-Resistant K. Pneumoniae ST258
Nathalie Chen, BS
University of Pittsburgh
11:00-11:15 Elucidating Molecular Mechanisms Underlying Successful Adaptation to Carbapenem Antimicrobials in High Risk Carbapenem Resistant Escherichia coli Lineages
William Shropshire, PhD
MD Anderson Cancer Center, Houston, TX.
11:15-11:30 Applications of Caenorhabditis elegans for Identification of Treatments Against Antimicrobial-Resistant Bacteria
Lois Armendariz, Rice University
11:30-12:00 Keynote Lecture
Resistance and New Drugs for Mycobacterium Tuberculosis
Kelly E. Dooley, MD, PhD
Vanderbilt University Medical Center
12:00-2:10 Lunch/Rapid Fire/Poster Session-Event Hall
12:00-12:40 Lunch
12:40-1:10 Rapid Fire
Defining the Mechanisms by Which Phage -Encoded Peptides Inhibit Cell Division in Gram-Negative Bacteria: A Promising Gateway Towards Alternative Therapeutics of Bacterial Infections
Arindam Naha, PhD, University of Texas Health Science Center at Houston, Poster 35
Changes in Antibiotic Susceptibilities Attributed to the Infection Environment
Caroline Black, MSc, Texas Tech University, Poster 32
Epidemiology of infections with Multidrug-Resistant Organisms in Patients with left Ventricular Assist Devices (LVADs)
Dierdre Axell-House, MD, Houston Methodist Research Institute, Poster 31
Identification of A Novel ST307 Sub-clade in Third Generation Cephalosporin Resistant Klebsiella Pneumoniae Causing Invasive Infections in the United States
Selvalakshmi Selvaraj Anand, BS, Rice University, Poster 36
ESBL Bacteremia During the First Year After Solid Organ Transplantation
German Contreras, MD, MSc, University of Texas Medical Branch, Poster 33
Different Mutations in the Rifampin Resistance-Determining Region (RRDR) of RpoB Cause Distinct Phenotypic Changes in Enterococcus faecium
Adeline Supandy, PhD, University of Pittsburgh, Poster 5
1:10-2:10 Poster Session, Poster #s 5, 31-58
Session 8
Conveners: Cesar A. Arias MD, PhD, Houston Methodist Research Institute and Weill Cornell Medical College, Houston, TX
2:10-3:10 Challenging Clinical Cases in Antimicrobial Resistance
Dierdre Axell-House, MD, Houston Methodist Research Institute and Weill Cornell Medical College, Houston, TX
Michael Rybak, PharmD, PhD, Wayne State University, Detroit, MI
Sam Shelburne, MD PhD, MD Anderson Cancer Center, Houston, TX
Session 9 ARLG Session 2
Clinical Research in Antimicrobial Resistance
Conveners: Vance Fowler, MD, Duke University
Anthony Harris, MD, University of Maryland
3:10-3:25 Mastermind-Ring
Michael Satlin, MD
Weill Cornell Medical College
3:25-3:40 OPTIMIZE-GNI
Thomas Lodise, PharmD, PhD
Albany College of Pharmacy and Health Sciences
3:40-3:55 Reproducibility of Pseudomonas aeruginosa Phage Susceptibility Testing: A Multicenter Comparison
Krupa Parmar, PhD
Mayo Clinic
3:55-4:10 DOOR Application Demonstration
Toshimitsu Hamasaki, PhD
George Washington University
4:10-4:30 Networking break
Session 10
Conveners: Rodrigo de Paula Baptista, PhD, Houston Methodist Research Institute, Houston, TX
Vincent Tam, PharmD, University of Houston, Houston, TX
4:30-4:50: B-lactamases in Stenotrophomonas maltophilia
Maria F. Mojica, PhD
Case Western Reserve University, Cleveland, OH
4:50-5:10 What’s Hot in the Treatment of S. aureus bacteremia
Vance Fowler, MD, MPH
Duke University, Durham, NC
Day 3-Friday, January 19, 2024
7:00-8:30 Registration
7:30-8:20 Career Mentoring: Careers in Microbiology and Diagnostic Stewardship-Event Hall
Audrey Wanger, PhD, University of Texas Health Science Center at Houston
Rodrigo de Paula Baptista, PhD, Houston Methodist Research Institute
Ed Septimus, MD, Harvard Medical School
Session 11
Convenors: Kevin Garey, PharmD, MS, University of Houston College of Pharmacy
Ed Septimus, MD, Harvard Medical School
8:30-8:35 Welcome
8:35-9:15 Keynote Presentation
Protecting Patients. Combatting Antimicrobial Resistance. An Update from CDC
Arjun Srinivasan, MD
Division of Healthcare Quality Promotion CDC
9:15-9:45 Antimicrobial Resistance from the Global Perspective
Debra Goff, PharmD
Ohio State University
9:45-10:15 Vendor show and Networking-Prefunction and Event Hall
Session 12
Conveners: Charlene Offiong, PharmD, Houston Health Department
Clare Gentry, MD, University of Texas Health Science Center
10:15-10:45 Optimizing Phage-Antibiotic Combination Therapy
Michael J. Rybak, PharmD, MPH, PhD
School of Medicine, Wayne State University
Session 13
Conveners: Kady Phe, PharmD, Baylor St Luke’s Medical Center
Anne Gonzales-Luna, PharmD, University of Houston College of Pharmacy
10:45-11:15 MDRO Colonization in ICU Patients: Results from the DYNAMITE Cohort Study
Max Adelman, MD
Houston Methodist Research Foundation
11:15-1:25 Lunch/Rapid Fire/Poster Session-Event Hall
11:15-11:55 Lunch
11:55-12:25 Rapid Fire Presentations
Situations Predisposing Primary Care Patients to Use Antibiotics Without a Prescription in the United States
Lindsey Laytner, PhD, Baylor College of Medicine, Poster 65
Sociodemographic Factors Associated with Knowledge of Antibiotic Risks Among an Outpatient Population
Eva Amenta, MD, Baylor College of Medicine/MEDVAMC, Poster 62
Characterization of Non-Carbapenemase Producing Carbapenem-Resistant Klebsiella pneumoniae in a Health System in Houston, Texas
Petar Jordanov, BS, Houston Methodist Research Institute, Poster 63
Influence of the COVID-19 Pandemic on Antimicrobial Resistance Patterns in Pediatric Group A Streptococcus Infections in Houston, TX
Aya Aboulhosn, MD, University of Texas Health Science Center Houston, and Children’s Memorial Hermann Hospital, Poster 61
Geospatial and Genomic Epidemiology of Clinical Burkholderia pseudomallei Isolates in Cambodia
Rachelle Koch, MSc, University of Texas Southwestern Medical Center, Poster 64
Basis of Fidaxomicin Resistance in Clostridioides difficile: A Systematic Review and Meta-Analysis
ThanhPhuong Le, PharmD, University of Houston, Poster 66
12:25-1:25 Posters Session, Poster #s 61-88
Session 14
Conveners: Ashley Drews, MD, Houston Methodist Research Institute
Jamie Thomas, PharmD, Memorial Hermann
1:25-2:00 Keynote Presentation
Myths in Infectious Disease
Elizabeth Dodds-Ashley, PharmD
Duke University
2:00-2:30 Evolving Epidemiology and Treatment of Invasive S. aureus Infections in Children
Sheldon Kaplan, MD
Texas Children’s Hospital and Baylor College of Medicine
2:30-3:00 Neonatal Stewardship
Michael Chang, MD
University of Texas Health Science Center Houston
Session 15 The Role of New Vaccines and Stewardship
Moderator Ed Septimus, MD, Harvard Medical School
3:00-3:55 RSV Vaccines: The Road to Licensure
Hana M. El Sahly, MD
Baylor College of Medicine
RSV Vaccines: Moving on to Recommendations
Robert Atmar, MD
Baylor College of Medicine
3:55 Closing Comments